Elucidating the role of androgen receptor in breast cancer

While¹⁹⁹ not²⁰⁰ as²⁰¹ common²⁰² of²⁰³ a²⁰⁴ concern²⁰⁵ as²⁰⁶ body²⁰⁷ weight²⁰⁸, muscularity²⁰⁹, amount²¹⁰ of²¹¹ head²¹² hair²¹³ and²¹⁴ body²¹⁵ hair²¹⁶, or²¹⁷ height²¹⁸, penis²¹⁹ size²²⁰ was²²¹ a²²² concern²²³ for²²⁴ 68.3²²⁵% of²²⁶ 200²²⁷ men²²⁸ in²²⁹ one²³⁰ study²³¹ [1²³²].

Concerns²³³ about²³⁴ genital²³⁵ appearance²³⁶ are²³⁷ unique²³⁸ compared²³⁹ to²⁴⁰ other²⁴¹ concerns²⁴² about²⁴³ physical²⁴⁴ appearance²⁴⁵.

A number sign (#) is used with this entry because hypogonadotropic hypogonadism-2 with or without anosmia (HH2) is caused by heterozygous mutation in the gene encoding fibroblast growth factor receptor-1 (FGFR1; 136350) on chromosome 8p11, sometimes in association with mutation in other genes, e.g., FGF8 (600483) and GNRHR (138850).

Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis.

There is evidence that mutation in 2 or more of these genes can work in combination (oligogenicity) to produce Gn RH-deficient conditions (summary by 21722705, images] [Full Text]" pmid="21722705"Sykiotis et al.

(2010), for example, demonstrated that of patients with an identifiable coding sequence mutation in 1 of 8 genes responsible for isolated Gn RH deficiency, 11% carried mutations in at least one other of these genes as well. (2013) analyzed 350 HH probands of European descent for mutation in 17 HH-associated genes.

This⁶³ study⁶⁴ used⁶⁵ haptic⁶⁶ stimuli⁶⁷ to⁶⁸ allow⁶⁹ assessment⁷⁰ of⁷¹ women’s⁷² size⁷³ recall⁷⁴ accuracy⁷⁵ for⁷⁶ the⁷⁷ first⁷⁸ time⁷⁹, as⁸⁰ well⁸¹ as⁸² examine⁸³ their⁸⁴ preferences⁸⁵ for⁸⁶ erect⁸⁷ penis⁸⁸ sizes⁸⁹ in⁹⁰ different⁹¹ relationship⁹² contexts⁹³.

Studies⁴⁴ of⁴⁵ women’s⁴⁶ penis⁴⁷ size⁴⁸ preferences⁴⁹ typically⁵⁰ have⁵¹ relied⁵² on⁵³ their⁵⁴ abstract⁵⁵ ratings⁵⁶ or⁵⁷ selecting⁵⁸ amongst⁵⁹ 2D⁶⁰, flaccid⁶¹ images⁶².

The vocal folds, also known commonly as vocal cords or voice reeds, are composed of twin infoldings of mucous membrane stretched horizontally, from back to front, across the larynx.

They vibrate, modulating the flow of air being expelled from the lungs during phonation.

Mutations were identified in 124 (35%) of the probands, and 24 (19%) of the mutation-positive probands carried at least 2 mutant alleles from different genes.

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